includes index, subject index

Contents: Advancing our knowledge in biochemistry, genetics, and microbiology through studies on tryptophan metabolism -- DNA primases -- Histone acetyltransferases -- Radical mechanisms of enzymatic catalysis -- Channeling of substrates and intermediates enzyme - catalyzed reactions -- Divergent evolution of enzymatic function -- Mechanistically diverse superfamilies and functionally -- Pten and myotubularin:novel phosphoinositide phosphatases -- Regulation of phosphoinositide-specific phospholipase -- Design and selection of novel -- Peroxisome proliferator - activated receptor and metabolic disease -- DNA topoisomerases: structure, function and mechanism -- DNA topoisomerases: structure, function and mechanism -- Fidelity of aminoacyl-trna selection on ribosome -- Kinetic and structural mechanisms -- Analysis of proteins and proteomes by mass spectrometry -- Transcriptional coactivator complexes -- Mechanisms underlying ubiquitination -- Synthesis and function of 3 - phoshorylated inositol lipids -- Folding of newly translated proteins in vivo: the role of molecular chaperones -- Regulation of actin filament network formation through -- Function, structure and mechanism of intracelluler copper trafficking proteins -- The signal recognition particle -- Mechanisms of viral membrane fusion and its inhibition.