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  <titleInfo>
    <title>Stroke therapy: basic preclinical, and clinical directions</title>
  </titleInfo>
  <name type="personal">
    <namePart>Miller, Leonard P.</namePart>
    <role>
      <roleTerm authority="marcrelator" type="text">creator</roleTerm>
    </role>
  </name>
  <name type="personal">
    <namePart>Miller, Leonard P.</namePart>
  </name>
  <typeOfResource>text</typeOfResource>
  <originInfo>
    <place>
      <placeTerm type="code" authority="marccountry">xxu</placeTerm>
    </place>
    <place>
      <placeTerm type="text">New York</placeTerm>
    </place>
    <publisher>Wiley-Liss</publisher>
    <dateIssued>1999</dateIssued>
    <issuance>monographic</issuance>
  </originInfo>
  <language>
    <languageTerm authority="iso639-2b" type="code">eng</languageTerm>
  </language>
  <physicalDescription>
    <form authority="marcform">print</form>
    <extent>xvi, 436 p.: ill.; 24cm.</extent>
  </physicalDescription>
  <tableOfContents>Contents: Basic science: Overview: Cellular and vascular pathophisiology of stroke -- Preclinical models of stroke -- Preclinical studies: Preclinical studies of glutamate receptor antagonists for the treatment of cerebral ischemia -- Aminobutyric acid agonists for neuroprotection -- Adenosine in ischemic brain injury -- Sodium and calcium channel modulators in stroke therapy -- Intracellular events associated with cerebral ischemia -- Nitric oxide: cellular and molecular pathways in stroke -- Free radicals in stroke -- Cellular inflammation in experimental ischemic stroke -- Apoptosis:DNA damage and repair in stroke -- Reparative approaches: Growth factors and other pharmacological treatments -- Clinical direction: Clinical trials for stroke: Design considerstions -- Thrombolytic treatment of thrombotic stroke -- Perioperative stroke, encephalopathy, and CNS dysfunction -- Stroke: present and future therapy.</tableOfContents>
  <note type="statement of responsibility">edited by Leonard P. Miller</note>
  <note>Includes bibliographical references and index.</note>
  <subject>
    <topic>Cerebrovascular disease</topic>
    <topic> Treatment</topic>
  </subject>
  <subject>
    <topic>Cerebrovascular disease</topic>
    <topic> Pathophysiology</topic>
  </subject>
  <subject>
    <topic>Cerebrovascular Disorders</topic>
    <topic>Therapy</topic>
  </subject>
  <classification authority="lcc">RC388.5.S8569</classification>
  <identifier type="isbn">0471183474</identifier>
  <recordInfo>
    <recordCreationDate encoding="marc">120716</recordCreationDate>
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